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doi: 10.1016/j.phrs.2024.107541 364 BravoJAForsythePChewMVEscaravageESavignacHMDinanTGet al

TB-500 works systemically

For preclinical in vivo models, researchers should consult species-specific pharmacokinetic data, as GIP receptor expression and GLP-1 receptor density vary across commonly used research species, which can affect dose-response relationships and translational relevance

These benefits were highlighted in 2019 when the Lancet published a meta-analysis of seven clinical trials showing that these treatments reduced hospital admission by 9%, all-cause mortality by 12% and deaths associated with kidney disease by 17% (Kristensen et al., 2019)

These medicines work by mimicking a naturally occurring hormone produced in the intestine that plays several important roles in metabolic regulation